l-Arginine Depletion and T-cell Responses: Fletcher et al. (2015) highlights that enzymatic depletion of l-arginine using pegylated arginase I (peg-Arg I) can suppress T-cell responses in tumors by inducing myeloid-derived suppressor cells (MDSC), which can enhance tumor growth. The study suggests that citrulline supplementation can rescue T-cell proliferation inhibited by peg-Arg I. Arginine Metabolism in […]

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