Cancer – Prostate – OncWonk – Dr Bier's Oncology Research Reviews

Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms

April 1, 2026

Comment: The “prostate stagnation” mechanism is biologically plausible for clearing environmental endocrine disruptors, yet it fails to move the needle on high-grade malignancy. The findings are unequivocal that higher ejaculations per month effectively lowers the risk for low-grade disease, likely by hindering the metabolic switch from citrate secretion to oxidation. However this protection does not […]

Ejaculation Frequency and Prostate Cancer Risk: A Narrative Review of Current Evidence

March 31, 2026

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| Cancer - Prostate

Comment: This review shows that while broad sexual behaviors offer no clear signal, ejaculation demonstrates a robust protective effect against low-grade disease. The “Prostate Stagnation Hypothesis”— says that the mechanical purging of chemical carcinogens and intraluminal crystalloids provides a credible defense. The evidence suggests a high-utility threshold: men reporting ≥ 21 ejaculations per month throughout adulthood […]

Updated dose–response meta-analysis of sexual activity and prostate cancer risk

March 30, 2026

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| Cancer - Prostate

Comment: This updated meta-analysis shows the failure of “sexual activity”—when broadly defined by intercourse frequency (OR = 1.02)—to provide any credible oncological signal, contrasted against the robust protective effect of mechanical prostatic clearance. The findings are unequivocal: while most sexual behaviors are statistical artifacts, ejaculation frequency demonstrates a statistically significant protective effect (OR = 0.83). […]

Usefulness of free PSA ratio to enhance detection of clinically significant prostate cancer in patients with PI-RADS<3 and PSA≤10

February 28, 2026

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| Cancer - Prostate, Screening

Comment: I have used the free PSA ratio (%fPSA) for years because it provides a reliable, cost-effective method to triage patients hovering in the PSA gray zone without immediately resorting to invasive procedures. Despite it being clear in the literature for decades, it is rare that I see it being used. The relatively recent availability […]

Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy

December 31, 2025

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| Cancer - Prostate, Cancers, Supplements

Comment: While the biomarker shifts and preclinical toxicity reductions in this review are biologically profound, it is always important to remember that mechanistic success rarely translates directly to human clinical outcomes. That being clear, on a risk-benefit assessment, there is no reason to not include genistein, and some clear signals to. The tangible significance of […]

Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

November 29, 2025

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| Cancer - Prostate, Prostatectomy, Radiation Therapy

Comment: This 15-year mortality data from ProtecT is a powerful addition to the 12-year patient-reported outcomes (PROs). underscoring the equivalence between the groups in terms of overall survival, but differences in functional outcomes. We already knew from the PROs analysis that generic quality-of-life scores were similar across all three groups (Active Monitoring, Prostatectomy, Radiotherapy) by […]

Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment

November 29, 2025

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| Cancer - Prostate, Prostatectomy, Radiation Therapy

Comment: This analysis provides critical long-term data and most importantly context for localized prostate cancer treatment decision making. The most striking takeaway is the lack of difference in cancer-specific, or overall survival among the three groups (prostatectomy, radiotherapy, and active monitoring) over the 12-year follow-up. Given that there is no difference in overall survival between […]

Intermittent vs Continuous Androgen Deprivation Therapy for Prostate Cancer: A Systematic Review and Meta-analysis

November 2, 2025

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| ADT - Androgen Deprivation, Cancer - Prostate

Comment: This meta-analysis provides important, ‘Moderate’ certainty evidence that supports a clinical approach that’s simple to implement. The key takeaway is the non-inferiority of intermittent androgen deprivation (IAD) regarding overall survival. While the summary notes minimal difference in overall quality of life, the qualitative data suggesting improvements in physical and sexual functioning is clinically significant. […]

Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy

October 26, 2025

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| Cancer - Prostate

Comment: This study showed that supplementing with a soy protein isolate didn’t impact PSA levels. However, a critical piece of context for this null finding is the dose they used. The 41 mg/day of total isoflavones used in this trial sits at the absolute low end of the 40-80 mg/day range typically tested in prostate cancer […]

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

October 25, 2025

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| Cancer - Prostate

Comment: This meta-analysis of observational studies serves as another robust rebuttal to the lingering concerns regarding soy’s impact on male hormonal health. It shows a significant reduction in prostate cancer risk in those with the highest consumption. With data representing over 266,000 participants and 21,000 cases, the findings suggest that soy isoflavones function as protective […]