OncWonk – Dr Bier's Oncology Research Reviews – An Informed Medicine Approach

OncWonk – The AI Assisted Naturopathic Oncology Database

October 7, 2025

Revolutionizing Naturopathic Oncology Research for Healthcare Professionals Contact Us for a complimentary 1 month trial. Introducing OncWonk, the groundbreaking AI-assisted Naturopathic Oncology Database meticulously curated to empower healthcare professionals with unparalleled access to cutting-edge research. This exclusive platform houses an expansive collection of nearly 120,000 articles from the medical literature dedicated to the exploration and […]

A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes

October 5, 2025

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| Breast Cancer, Soy

Comment: The damaging myth that soy intake is negative still persists despite all evidence to the contrary. This is another study showing that in breast cancer not only is it not harmful, but protective. Summary: Clinical Bottom Line This narrative review concludes that women with breast cancer can safely consume soy foods, regardless of their […]

Coffee and tea intake and survival of cancer patients: a systematic review and meta-analysis

October 5, 2025

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| Coffee & Tea, Colon Cancer

Comment: I love my coffee – even roast my own beans. I also gave it up for about a dozen years because I was told how bad it was for me. As the research has continued to come it, it shows just how wrong that thinking is. Both coffee and tea have significant benefits. Summary […]

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

October 3, 2025

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| Anti-parasitics

Comment: The trend towards drug repurposing for cancer treatment has a basic underlying assumption that it is safe, even if not proven effective. This study shows that may not be the case. Summary: Clinical Bottom Line This early-phase study was stopped prematurely due to a complete lack of efficacy and concerning signals of potential […]

Arginine & Citrulline in Immunotherapy

September 28, 2025

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| Immunotherapy

l-Arginine Depletion and T-cell Responses: Fletcher et al. (2015) highlights that enzymatic depletion of l-arginine using pegylated arginase I (peg-Arg I) can suppress T-cell responses in tumors by inducing myeloid-derived suppressor cells (MDSC), which can enhance tumor growth. The study suggests that citrulline supplementation can rescue T-cell proliferation inhibited by peg-Arg I. Arginine Metabolism in […]

Sucralose consumption ablates cancer immunotherapy response through microbiome disruption.

September 28, 2025

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| Immunotherapy, Nutrition

Comment: Interesting mechanism regarding the depletion of arginine, and restoration of function with arginine or citrulline supplementation. Does that indicate that supplementing with those would benefit people on immunotherapy regardless – there is data to support that it does, see here. Summary: Sucralose Consumption Ablates Cancer Immunotherapy Response Through Microbiome Disruption Clinical Bottom Line This […]

Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

September 28, 2025

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| Vitamin D

Comment I’ve been using a basic rule of thumb – D3 – D2 = real vitamin D This study doesn’t exactly say that, but does give me a basis for my general statement that D2 may be worse than no D at all as it negatively impacts D3 status. Summary Title of the Article: […]

Animal and plant protein usual intakes are not adversely associated with all-cause, cardiovascular disease-, or cancer-related mortality risk: an NHANES III analysis

September 20, 2025

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| Nutrition

Comment: Another study showing that animal protein intake does not increase death rates. In fact, this study links higher animal protein intake to a reduced risk of cancer, albeit small. Clinical Bottom Line This large cohort study found no association between the usual intake of either animal or plant protein and the risk of […]

Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD

September 20, 2025

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| Colon Cancer, Nutrition

COMMENT: The application to sugary drinks is obvious, however I would extend it to fruit and fruit juice consumption as well which both have high amounts of fructose and glucose, as well as sucrose. As examples: Fruit / Juice Serving Size Fructose (g) Glucose (g) Total Sugars (g) Whole Fruits Apple […]