Treatments – Conventional – Page 3 – OncWonk – Dr Bier’s Oncology Research Reviews

Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer

November 15, 2025

| Cancer - Breast, Radiation Therapy, Treatments – Conventional

Comment: This 10-year follow-up of the PRIME II trial reinforces a crucial point for managing older patients with low-risk, hormone-positive breast cancer. Yes, omitting radiotherapy after breast-conserving surgery increased the 10-year local recurrence rate significantly (from 0.9% to 9.5%). However, the definitive, practice-changing finding is that this 10-fold increase in local recurrence had zero impact on […]

Intermittent vs Continuous Androgen Deprivation Therapy for Prostate Cancer: A Systematic Review and Meta-analysis

November 2, 2025

| No Comments

| ADT - Androgen Deprivation, Cancer - Prostate

Comment: This meta-analysis provides important, ‘Moderate’ certainty evidence that supports a clinical approach that’s simple to implement. The key takeaway is the non-inferiority of intermittent androgen deprivation (IAD) regarding overall survival. While the summary notes minimal difference in overall quality of life, the qualitative data suggesting improvements in physical and sexual functioning is clinically significant. […]

The Intriguing Thyroid Hormones-Lung Cancer Association as Exemplification of the Thyroid Hormones-Cancer Association: Three Decades of Evolving Research

November 1, 2025

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| Cancers, Immunotherapy & Targeted Therapies, Medications - General Pharmaceuticals

Comment: This is a fascinating review of a complex topic. The key clinical pearl here is the paradoxical finding that treatment-induced hypothyroidism (from TKIs/ICPis) often correlates with a favorable prognosis. It underscores the need to closely monitor thyroid function in these patients—not just as a side effect to be managed, but as a potential prognostic […]

Sucralose consumption ablates cancer immunotherapy response through microbiome disruption.

September 28, 2025

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| Immunotherapy & Targeted Therapies, Nutrition

Comment: Interesting mechanism regarding the depletion of arginine, and restoration of function with arginine or citrulline supplementation. Does that indicate that supplementing with those would benefit people on immunotherapy regardless – there is data to support that it does, see here. Summary: Sucralose Consumption Ablates Cancer Immunotherapy Response Through Microbiome Disruption Clinical Bottom Line This […]