Comment: Two underlying assumptions of the repurposed drug movement is that since the medications are already approved they are both safe and can achieve clinically meaningful levels. The issue is that using an anti-parasitic short term is very different than trying to get higher blood levels long term. This trial shows delayed, grade 3 liver […]
Comment: For years, people have been inappropriately scared of soy both in terms of causing breast cancer and negatively impacting progression once they have it. There is a group of people out there who are continuing to promote that despite all evidence to the contrary. The key finding of this study is not just that […]
Comment: This meta-analysis of observational studies serves as another robust rebuttal to the lingering concerns regarding soy’s impact on male hormonal health. It shows a significant reduction in prostate cancer risk in those with the highest consumption. With data representing over 266,000 participants and 21,000 cases, the findings suggest that soy isoflavones function as protective […]
Comment: This study presents a provocative and counter-intuitive finding that directly challenges the conventional wisdom surrounding soy and prostate cancer. While many previous studies have suggested a protective role for soy, this large, prospective Japanese cohort finds the opposite: the highest intake of soy foods was associated with a 76% increased risk of prostate cancer […]
Comment: A common question from breast cancer survivors is whether soy is safe to eat. This post breaks down a 2012 Chinese study that explored this topic. The researchers found a positive association between high soy intake and improved survival for breast cancer patients, particularly those with ER-positive tumors. Summary: Clinical Bottom Line This prospective […]
Comment: A study looking at the impact of phytonutrients, including soy and tea. The strongest evidence is for soy isoflavones. Summary: Clinical Bottom Line This systematic review of observational studies provides “Probable” evidence that higher soy isoflavone consumption is associated with a reduced risk of breast cancer recurrence, particularly for postmenopausal and ER-positive survivors. Similarly, […]
Comment: This article shows a benefit to soy intake for ER+/PR+ patients taking AI medications, but not with tamoxifen. Summary: Clinical Bottom Line This prospective cohort study found a significant association between high dietary soy isoflavone intake (defined as >42.3 mg/day) and a reduced risk of breast cancer recurrence among postmenopausal patients receiving adjuvant endocrine […]
Comment: This study shows that in breast cancer patients, soy consumption was associated with reduced rates of both recurrence and death from breast cancer, as well as improved overall survival, not only breast cancer specific survival. As always, the focus needs to be on overall survival as the important metric, and this one shows that […]
Comment: This article was a source of great concern to patients and oncologists when it first came out, and still is. As published in ASCO:“Using antioxidants and other dietary supplements before and during adjuvant chemotherapy for breast cancer may increase the risk of recurrence and “to a lesser extent, death,” according to an analysis of […]
Comment: This is a study that is often cited by people who advocate for fenbendazole in cancer treatment, however it doesn’t take much looking to see that not only does it not support it’s use, but there are clear potential danger signals. First, this is a mouse study with a total of 19 mice across […]
