Comment: Two underlying assumptions of the repurposed drug movement is that since the medications are already approved they are both safe and can achieve clinically meaningful levels. The issue is that using an anti-parasitic short term is very different than trying to get higher blood levels long term. This trial shows delayed, grade 3 […]
Comment: For years, people have been inappropriately scared of soy both in terms of causing breast cancer and negatively impacting progression once they have it. There is a group of people out there who are continuing to promote that despite all evidence to the contrary. The key finding of this study is not just that […]
Comment: comment here Summary: Clinical Bottom Line This meta-analysis of observational studies suggests a significant association between higher consumption of soy foods and a reduced risk of prostate cancer. Specifically, total soy intake (RR 0.71), unfermented soy (RR 0.65), and dietary isoflavones genistein and daidzein were linked to lower risk. However, this finding should […]
Comment: This study presents a provocative and counter-intuitive finding that directly challenges the conventional wisdom surrounding soy and prostate cancer. While many previous studies have suggested a protective role for soy, this large, prospective Japanese cohort finds the opposite: the highest intake of soy foods was associated with a 76% increased risk of prostate cancer […]
Comment: A common question from breast cancer survivors is whether soy is safe to eat. This post breaks down a 2012 Chinese study that explored this topic. The researchers found a positive association between high soy intake and improved survival for breast cancer patients, particularly those with ER-positive tumors. Summary: Clinical Bottom Line This prospective […]
Comment: A study looking at the impact of phytonutrients, including soy and tea. The strongest evidence is for soy isoflavones. Summary: Clinical Bottom Line This systematic review of observational studies provides “Probable” evidence that higher soy isoflavone consumption is associated with a reduced risk of breast cancer recurrence, particularly for postmenopausal and ER-positive survivors. Similarly, […]
Comment: This article shows a benefit to soy intake for ER+/PR+ patients taking AI medications, but not with tamoxifen. Summary: Clinical Bottom Line This prospective cohort study found a significant association between high dietary soy isoflavone intake (defined as >42.3 mg/day) and a reduced risk of breast cancer recurrence among postmenopausal […]
Comment: This study shows that in breast cancer patients, soy consumption was associated with reduced rates of both recurrence and death from breast cancer, as well as improved overall survival, not only breast cancer specific survival. Summary: Clinical Bottom Line: This large, population-based cohort study of 5,033 Chinese breast cancer survivors found that higher soy […]
Comment: This article was a source of great concern to patients and oncologists when it first came out, and still is. As published in ASCO:“Using antioxidants and other dietary supplements before and during adjuvant chemotherapy for breast cancer may increase the risk of recurrence and “to a lesser extent, death,” according to an analysis of […]
Comment: This article shows an increase in ovarian cancer risk with longer term use of HRT. Both estrogen alone and estrogen-progesterone showed an increase, and the association was stronger in the cohort studies than the case control studies, which are the more robust . Cohort Studies: The 21 cohort studies showed a slightly higher […]
