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OncWonk – Dr Bier’s Oncology Research Reviews

OncWonk – Dr Bier’s Oncology Research Reviews

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Category: Medications – General Pharmaceuticals

The Intriguing Thyroid Hormones-Lung Cancer Association as Exemplification of the Thyroid Hormones-Cancer Association: Three Decades of Evolving Research

November 1, 2025
| No Comments
| Cancers, Immunotherapy & Targeted Therapies, Medications - General Pharmaceuticals

Comment: This is a fascinating review of a complex topic. The key clinical pearl here is the paradoxical finding that treatment-induced hypothyroidism (from TKIs/ICPis) often correlates with a favorable prognosis. It underscores the need to closely monitor thyroid function in these patients—not just as a side effect to be managed, but as a potential prognostic […]

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Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer

October 26, 2025
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| Cancer - Ovarian, Repurposed Drugs - Anti-parasitics, Metformin

Comment: This study provides crucial clarity on the fenbendazole story. The key takeaway is the stark difference between in vitro (lab dish) and in vivo (live animal) results. While FZ can kill cancer cells in a dish, this study demonstrates it completely fails in live models when given in its natural form. The reason is […]

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Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial

October 26, 2025
| No Comments
| Repurposed Drugs - Anti-parasitics, Metformin

Comment: Two underlying assumptions of the repurposed drug movement is that since the medications are already approved they are both safe and can achieve clinically meaningful levels. The issue is that using an anti-parasitic short term is very different than trying to get higher blood levels long term. This trial shows delayed, grade 3 liver […]

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Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins

October 14, 2025
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| Repurposed Drugs - Anti-parasitics, Metformin

Comment: This is a study that is often cited by people who advocate for fenbendazole in cancer treatment, however it doesn’t take much looking to see that not only does it not support it’s use, but there are clear potential danger signals. First, this is a mouse study with a total of 19 mice across […]

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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

October 3, 2025
| No Comments
| Repurposed Drugs - Anti-parasitics, Metformin

Comment: The trend towards drug repurposing for cancer treatment has a basic underlying assumption that it is safe, even if not proven effective. This study shows that may not be the case with 4/10 patients showing hyperprogression.    Summary: Clinical Bottom Line This early-phase study was stopped prematurely due to a complete lack of efficacy […]

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This work is licensed under CC BY-NC 4.0 Excludes third-party study data & figures.

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