Comment: This study provides crucial clarity on the fenbendazole story. The key takeaway is the stark difference between in vitro (lab dish) and in vivo (live animal) results. While FZ can kill cancer cells in a dish, this study demonstrates it completely fails in live models when given in its natural form. The reason is […]
Comment: Two underlying assumptions of the repurposed drug movement is that since the medications are already approved they are both safe and can achieve clinically meaningful levels. The issue is that using an anti-parasitic short term is very different than trying to get higher blood levels long term. This trial shows delayed, grade 3 liver […]
Comment: This is a study that is often cited by people who advocate for fenbendazole in cancer treatment, however it doesn’t take much looking to see that not only does it not support it’s use, but there are clear potential danger signals. First, this is a mouse study with a total of 19 mice across […]
Comment: The trend towards drug repurposing for cancer treatment has a basic underlying assumption that it is safe, even if not proven effective. This study shows that may not be the case with 4/10 patients showing hyperprogression. Summary: Clinical Bottom Line This early-phase study was stopped prematurely due to a complete lack of efficacy […]
