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OncWonk – Dr Bier's Oncology Research Reviews

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Tag: Vitamin D

Vitamin D supplementation increases objective response rate and prolongs progression-free time in patients with advanced melanoma undergoing anti-PD-1 therapy

February 3, 2026
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| Cancer - Melanoma, Immunotherapy & Targeted Therapies

Comment: The clinical management of advanced melanoma has been transformed by the arrival of anti-PD-1 immunotherapy, yet we frequently observe a frustrating divergence in response among patients receiving the same conventional standard-of-care. This observational cohort study of 200 patients identifies a critical metabolic requirement that likely dictates the success of these conventional treatments: serum vitamin […]

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Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer – The SUNSHINE Randomized Clinical Trial

December 20, 2025
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| Cancer - Colon, Supplements

Comment: These findings are another, again highlight the massive, untapped potential of nutritional synergy with conventional treatment. Adding just 4,000 IU of Vitamin D3 didn’t just improve serum levels,; it translated to a tangible clinical victory—a 36% reduction in the risk of progression or death. This indicates that Vitamin D acts as a ‘force multiplier’ […]

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Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis

November 19, 2025
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| Cancers

💡 Comment: The Moderate certainty evidence presented in this meta-analysis underscores the profound impact of circulating 25-hydroxyvitamin D [25(OH)D] levels on cancer patient outcomes. Although this analysis is limited to colorectal cancer, breast cancer, and lymphoma, there’s no reason to believe it doesn’t apply across the board. Yes it is based on observational studies and […]

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Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

September 28, 2025
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| Miscellaneous

Comment I’ve been using a basic rule of thumb –  D3 – D2 = real vitamin D This study doesn’t exactly say that, but does give me a basis for my general statement that D2 may be worse than no D at all as it negatively impacts D3 status.   Summary Title of the Article: […]

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This work is licensed under CC BY-NC 4.0 Excludes third-party study data & figures.

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