OncWonk – Dr Bier's Oncology Research Reviews – Page 12

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

October 3, 2025

| Repurposed Drugs - Anti-parasitics, Metformin

Comment: The trend towards drug repurposing for cancer treatment has a basic underlying assumption that it is safe, even if not proven effective. This study shows that may not be the case with 4/10 patients showing hyperprogression. Summary: Clinical Bottom Line This early-phase study was stopped prematurely due to a complete lack of efficacy […]

Sucralose consumption ablates cancer immunotherapy response through microbiome disruption.

September 28, 2025

| No Comments

| Immunotherapy & Targeted Therapies, Nutrition

Comment: Interesting mechanism regarding the depletion of arginine, and restoration of function with arginine or citrulline supplementation. Does that indicate that supplementing with those would benefit people on immunotherapy regardless – there is data to support that it does, see here. Summary: Sucralose Consumption Ablates Cancer Immunotherapy Response Through Microbiome Disruption Clinical Bottom Line This […]

Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

September 28, 2025

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| Miscellaneous

Comment I’ve been using a basic rule of thumb – D3 – D2 = real vitamin D This study doesn’t exactly say that, but does give me a basis for my general statement that D2 may be worse than no D at all as it negatively impacts D3 status. Summary Title of the Article: […]

Animal and plant protein usual intakes are not adversely associated with all-cause, cardiovascular disease-, or cancer-related mortality risk: an NHANES III analysis

September 20, 2025

| No Comments

| Nutrition

Comment: Another study showing that animal protein intake does not increase death rates. In fact, this study links higher animal protein intake to a reduced risk of cancer, albeit small. Clinical Bottom Line This large cohort study found no association between the usual intake of either animal or plant protein and the risk of […]

Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD

September 20, 2025

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| Cancer - Colon, Nutrition

COMMENT: The application to sugary drinks is obvious, however I would extend it to fruit and fruit juice consumption as well which both have high amounts of fructose and glucose, as well as sucrose. As examples: Fruit / Juice Serving Size Fructose (g) Glucose (g) Total Sugars (g) Whole Fruits Apple […]