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OncWonk – Dr Bier's Oncology Research Reviews

OncWonk – Dr Bier's Oncology Research Reviews

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Category: Treatments – Integrative

Improved survival in patients with end-stage cancer treated with coenzyme Q(10) and other antioxidants: a pilot study

November 30, 2025
| No Comments
| Cancers, Supplements

💬Comment: This is a pilot study and has a lot of weaknesses in terms of study design. However it also shows  a median actual survival time 40% longer than predicted—17 months versus 12 months—in this highly selected group of end-stage patients. The authors rightly point out the major methodological flaw of a retrospective, non-randomized, and […]

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Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer

November 28, 2025
| No Comments
| Cancer - Breast, Sleep

Comment: This is a study I go back to again and again as it’s well designed and demonstrates how important quality sleep is not just for quality of life, but for a significant improvement in overall survival.We have many tools to help with sleep, including reminding people of the importance of it. This study highlights […]

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Dietary isoflavone intake is not statistically significantly associated with breast cancer risk in the Multiethnic Cohort

November 23, 2025
| No Comments
| Cancer - Breast, Nutrition

Comment: For years, the key question surrounding soy intake and breast cancer has been about safety: Does soy increase risk, especially in low-consuming Western populations? Numerous studies have shown safety, however most studies have been in an Asian population. This large, prospective study drawn from the Multiethnic Cohort (MEC) provides a clear and reassuring answer for […]

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Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study

October 26, 2025
| No Comments
| Cancer - Breast, Nutrition

Comment: For years, people have been inappropriately scared of soy both in terms of causing breast cancer and negatively impacting progression once they have it. There is a group of people out there who are continuing to promote that despite all evidence to the contrary. The key finding of this study is not just that […]

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Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)

October 23, 2025
| No Comments
| Cancer - Breast, Supplements

Comment: This article was a source of great concern to patients and oncologists when it first came out, and still is. As published in ASCO:“Using antioxidants and other dietary supplements before and during adjuvant chemotherapy for breast cancer may increase the risk of recurrence and “to a lesser extent, death,” according to an analysis of […]

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A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes

October 5, 2025
| No Comments
| Cancer - Breast, Nutrition

Comment: The evidence supporting the safety of soy has been building for a long time, yet the damaging myth that it is ‘dangerous’ persists—driven almost entirely by preclinical models. This 2025 review serves as a definitive corrective. It confirms that in human patients, soy intake is not only safe but consistently associated with better outcomes—specifically […]

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Sucralose consumption ablates cancer immunotherapy response through microbiome disruption.

September 28, 2025
| No Comments
| Immunotherapy & Targeted Therapies, Nutrition

Comment: Interesting mechanism regarding the depletion of arginine, and restoration of function with arginine or citrulline supplementation. Does that indicate that supplementing with those would benefit people on immunotherapy regardless – there is data to support that it does, see here. Summary: Sucralose Consumption Ablates Cancer Immunotherapy Response Through Microbiome Disruption Clinical Bottom Line This […]

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Animal and plant protein usual intakes are not adversely associated with all-cause, cardiovascular disease-, or cancer-related mortality risk: an NHANES III analysis

September 20, 2025
| No Comments
| Nutrition

Comment: Another study showing that animal protein intake does not increase death rates. In fact, this study links higher animal protein intake to a reduced risk of cancer, albeit small. Clinical Bottom Line   This large cohort study found no association between the usual intake of either animal or plant protein and the risk of […]

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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD

September 20, 2025
| No Comments
| Cancer - Colon, Nutrition

COMMENT: The application to sugary drinks is obvious, however I would extend it to fruit and fruit juice consumption as well which both have high amounts of fructose and glucose, as well as sucrose. As examples: Fruit / Juice Serving Size Fructose (g) Glucose (g) Total Sugars (g) Whole Fruits         Apple […]

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