Comment: The efficacy of mammography debate is a conflict between the allure of the “early detection saves lives” mantra and the reality that these screenings have never demonstrated a statistically significant improvement in all-cause mortality. The traditional clinical focus on universal mammography ignores the underlying reality that the tradeoff between harms and benefits has been […]
Comment: The central justification for aspirin use in primary prevention has long relied on the “Legacy Effect”—the theory that years of early exposure act as a biological investment, paying dividends in reduced cancer risk decades later. This follow-up to the ASPREE trial effectively demolishes that hypothesis for older adults. We are witnessing a stark collision […]
Comment: The clinical management of advanced melanoma has been transformed by the arrival of anti-PD-1 immunotherapy, yet we frequently observe a frustrating divergence in response among patients receiving the same conventional standard-of-care. This observational cohort study of 200 patients identifies a critical metabolic requirement that likely dictates the success of these conventional treatments: serum vitamin […]
Comment: Although conventional treatments for breast cancer has made astounding improvements over the 35 years that I’ve been in the field, we have to acknowledge that along with it comes a long-term price paid by the patient’s systemic health. This study provides a definitive signal on the iatrogenic risks associated with the standard-of-care. The clinical […]
