Cancers – Page 3 – OncWonk – Dr Bier's Oncology Research Reviews

Metronomic chemotherapy with oral vinorelbine (mVNR) and capecitabine (mCAPE) in advanced HER2-negative breast cancer patients: is it a way to optimize disease control? Final results of the VICTOR-2 study

October 26, 2025

| Cancer - Breast, Cancer - Breast TNBC, Metronomic Chemo

Comment: This study presents a very practical and appealing option for managing advanced HER2-negative breast cancer in the palliative setting. The key takeaway is the dual advantage of this all-oral metronomic regimen: it demonstrates clinically relevant activity while maintaining an exceptionally low toxicity profile. However, the regimen’s main strength is its safety and convenience. Being […]

Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy

October 26, 2025

| No Comments

| Cancer - Prostate, Soy

Comment: This study showed that supplementing with a soy protein isolate didn’t impact PSA levels. However, a critical piece of context for this null finding is the dose they used. The 41 mg/day of total isoflavones used in this trial sits at the absolute low end of the 40-80 mg/day range typically tested in prostate cancer […]

Respiratory viral infections awaken metastatic breast cancer cells in lungs

October 26, 2025

| No Comments

| Cancer - Breast, Cancers

Comment: This is an interesting and potentially alarming one. I’m sure we’ve all noted times where a stable patient started progressing after getting an infection. This study shows an association of SARS-CoV-2 infection with a nearly two-fold increase in cancer-specific mortality (UK Biobank) and a 44% higher rate of lung metastases in breast cancer patients […]

Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women

October 26, 2025

| No Comments

| Cancer - Breast, Soy

Comment: This meta-analysis is a classic example of how pooling heterogeneous and methodologically different studies can create confusion. In general I am always suspicious of meta-analyses for that reason. Although it is possible that there is a biological reason for the studies on Asian women to be different than on Western, it is also possible […]

Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study

October 26, 2025

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| Cancer - Breast, Soy

Comment: For years, people have been inappropriately scared of soy both in terms of causing breast cancer and negatively impacting progression once they have it. There is a group of people out there who are continuing to promote that despite all evidence to the contrary. The key finding of this study is not just that […]

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

October 25, 2025

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| Cancer - Prostate, Soy

Comment: comment here Summary: Clinical Bottom Line This meta-analysis of observational studies suggests a significant association between higher consumption of soy foods and a reduced risk of prostate cancer. Specifically, total soy intake (RR 0.71), unfermented soy (RR 0.65), and dietary isoflavones genistein and daidzein were linked to lower risk. However, this finding should […]

Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study

October 25, 2025

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| Cancer - Prostate, Soy

Comment: This study presents a provocative and counter-intuitive finding that directly challenges the conventional wisdom surrounding soy and prostate cancer. While many previous studies have suggested a protective role for soy, this large, prospective Japanese cohort finds the opposite: the highest intake of soy foods was associated with a 76% increased risk of prostate cancer […]

Positive effects of soy isoflavone food on survival of breast cancer patients in China

October 25, 2025

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| Cancer - Breast, Soy

Comment: A common question from breast cancer survivors is whether soy is safe to eat. This post breaks down a 2012 Chinese study that explored this topic. The researchers found a positive association between high soy intake and improved survival for breast cancer patients, particularly those with ER-positive tumors. Summary: Clinical Bottom Line This prospective […]

Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

October 25, 2025

| No Comments

| Cancer - Breast, Coffee & Tea, Soy

Comment: A study looking at the impact of phytonutrients, including soy and tea. The strongest evidence is for soy isoflavones. Summary: Clinical Bottom Line This systematic review of observational studies provides “Probable” evidence that higher soy isoflavone consumption is associated with a reduced risk of breast cancer recurrence, particularly for postmenopausal and ER-positive survivors. Similarly, […]

Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy

October 25, 2025

| No Comments

| Cancer - Breast, Soy

Comment: This article shows a benefit to soy intake for ER+/PR+ patients taking AI medications, but not with tamoxifen. Summary: Clinical Bottom Line This prospective cohort study found a significant association between high dietary soy isoflavone intake (defined as >42.3 mg/day) and a reduced risk of breast cancer recurrence among postmenopausal […]