OncWonk – Dr Bier's Oncology Research Reviews – Page 3

Metronomic Capecitabine Plus Aromatase Inhibitor as Initial Therapy in Patients With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer

October 26, 2025

Comment: The MECCA trial, while certainly not practice-changing, provides an important signal for the potential of metronomic chemotherapy. The key takeaway is the therapeutic window. Achieving a 9-month PFS benefit and a positive OS trend with a regimen that produced Grade 3 adverse events in only 15.1% of patients is compelling. This highlights the central […]

Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer

October 26, 2025

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| Anti-parasitics, Cancer - Ovarian

Comment: This study provides crucial clarity on the fenbendazole story. The key takeaway is the stark difference between in vitro (lab dish) and in vivo (live animal) results. While FZ can kill cancer cells in a dish, this study demonstrates it completely fails in live models when given in its natural form. The reason is […]

NatWonk – Our Sibling Site

October 26, 2025

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| Uncategorized

NatWonk – Naturopathic Research Reviews

Metronomic chemotherapy with oral vinorelbine (mVNR) and capecitabine (mCAPE) in advanced HER2-negative breast cancer patients: is it a way to optimize disease control? Final results of the VICTOR-2 study

October 26, 2025

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| Cancer - Breast, Cancer - Breast TNBC, Metronomic Chemo

Comment: This study presents a very practical and appealing option for managing advanced HER2-negative breast cancer in the palliative setting. The key takeaway is the dual advantage of this all-oral metronomic regimen: it demonstrates clinically relevant activity while maintaining an exceptionally low toxicity profile. However, the regimen’s main strength is its safety and convenience. Being […]

Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy

October 26, 2025

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| Cancer - Prostate, Soy

Comment: This study showed that supplementing with a soy protein isolate didn’t impact PSA levels. However, a critical piece of context for this null finding is the dose they used. The 41 mg/day of total isoflavones used in this trial sits at the absolute low end of the 40-80 mg/day range typically tested in prostate cancer […]

Respiratory viral infections awaken metastatic breast cancer cells in lungs

October 26, 2025

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| Cancer - Breast, Cancers

Comment: This is an interesting and potentially alarming one. I’m sure we’ve all noted times where a stable patient started progressing after getting an infection. This study shows an association of SARS-CoV-2 infection with a nearly two-fold increase in cancer-specific mortality (UK Biobank) and a 44% higher rate of lung metastases in breast cancer patients […]

Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women

October 26, 2025

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| Cancer - Breast, Soy

Comment: This meta-analysis is a classic example of how pooling heterogeneous and methodologically different studies can create confusion. In general I am always suspicious of meta-analyses for that reason. Although it is possible that there is a biological reason for the studies on Asian women to be different than on Western, it is also possible […]

Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial

October 26, 2025

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| Anti-parasitics

Comment: Two underlying assumptions of the repurposed drug movement is that since the medications are already approved they are both safe and can achieve clinically meaningful levels. The issue is that using an anti-parasitic short term is very different than trying to get higher blood levels long term. This trial shows delayed, grade 3 […]

Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study

October 26, 2025

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| Cancer - Breast, Soy

Comment: For years, people have been inappropriately scared of soy both in terms of causing breast cancer and negatively impacting progression once they have it. There is a group of people out there who are continuing to promote that despite all evidence to the contrary. The key finding of this study is not just that […]

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

October 25, 2025

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| Cancer - Prostate, Soy

Comment: comment here Summary: Clinical Bottom Line This meta-analysis of observational studies suggests a significant association between higher consumption of soy foods and a reduced risk of prostate cancer. Specifically, total soy intake (RR 0.71), unfermented soy (RR 0.65), and dietary isoflavones genistein and daidzein were linked to lower risk. However, this finding should […]