OncWonk – Dr Bier's Oncology Research Reviews – Page 4

Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study

October 25, 2025

Comment: This study presents a provocative and counter-intuitive finding that directly challenges the conventional wisdom surrounding soy and prostate cancer. While many previous studies have suggested a protective role for soy, this large, prospective Japanese cohort finds the opposite: the highest intake of soy foods was associated with a 76% increased risk of prostate cancer […]

Positive effects of soy isoflavone food on survival of breast cancer patients in China

October 25, 2025

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| Cancer - Breast, Soy

Comment: A common question from breast cancer survivors is whether soy is safe to eat. This post breaks down a 2012 Chinese study that explored this topic. The researchers found a positive association between high soy intake and improved survival for breast cancer patients, particularly those with ER-positive tumors. Summary: Clinical Bottom Line This prospective […]

Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies

October 25, 2025

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| Cancer - Breast, Coffee & Tea, Soy

Comment: A study looking at the impact of phytonutrients, including soy and tea. The strongest evidence is for soy isoflavones. Summary: Clinical Bottom Line This systematic review of observational studies provides “Probable” evidence that higher soy isoflavone consumption is associated with a reduced risk of breast cancer recurrence, particularly for postmenopausal and ER-positive survivors. Similarly, […]

Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy

October 25, 2025

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| Cancer - Breast, Soy

Comment: This article shows a benefit to soy intake for ER+/PR+ patients taking AI medications, but not with tamoxifen. Summary: Clinical Bottom Line This prospective cohort study found a significant association between high dietary soy isoflavone intake (defined as >42.3 mg/day) and a reduced risk of breast cancer recurrence among postmenopausal […]

Soy Food Intake and Breast Cancer Survival

October 25, 2025

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| Cancer - Breast, Soy

Comment: This study shows that in breast cancer patients, soy consumption was associated with reduced rates of both recurrence and death from breast cancer, as well as improved overall survival, not only breast cancer specific survival. Summary: Clinical Bottom Line: This large, population-based cohort study of 5,033 Chinese breast cancer survivors found that higher soy […]

Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)

October 23, 2025

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| Antioxidants, Cancer - Breast, Supplements, Vitamin B12

Comment: This article was a source of great concern to patients and oncologists when it first came out, and still is. As published in ASCO:“Using antioxidants and other dietary supplements before and during adjuvant chemotherapy for breast cancer may increase the risk of recurrence and “to a lesser extent, death,” according to an analysis of […]

The risk of ovarian cancer in hormone replacement therapy users: a systematic review and meta-analysis

October 19, 2025

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| Cancer - Ovarian

Comment: This article shows an increase in ovarian cancer risk with longer term use of HRT. Both estrogen alone and estrogen-progesterone showed an increase, and the association was stronger in the cohort studies than the case control studies, which are the more robust . Cohort Studies: The 21 cohort studies showed a slightly higher […]

The benefits and risks of menopause hormone therapy for the cardiovascular system in postmenopausal women: a systematic review and meta-analysis

October 15, 2025

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| HRT - Hormone Replacement Therapy

Comment: Although there are some potential benefits to hormone replacement therapy, there are significant risks associated as well. This study is another one that shows significant cardiovascular harm, with increases in stroke and thromboembolism.` Summary: Clinical Bottom Line This high-certainty meta-analysis demonstrates that for the general postmenopausal population, menopause hormone therapy (MHT) is […]

Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins

October 14, 2025

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| Anti-parasitics

Comment: This is a study that is often cited by people who advocate for fenbendazole in cancer treatment, however it doesn’t take much looking to see that not only does it not support it’s use, but there are clear potential danger signals. First, this is a mouse study with a total of 19 mice across […]

OncWonk – The AI Assisted Naturopathic Oncology Database

October 7, 2025

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| Uncategorized

Revolutionizing Naturopathic Oncology Research for Healthcare Professionals Contact Us for a complimentary 1 month trial. Introducing OncWonk, the groundbreaking AI-assisted Naturopathic Oncology Database meticulously curated to empower healthcare professionals with unparalleled access to cutting-edge research. This exclusive platform houses an expansive collection of nearly 120,000 articles from the medical literature dedicated to the exploration and […]